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Paysandú
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- Basílica Catedral Nuestra Señora del Rosario · Centro: Paysandú's large 19th-century cathedral faces Plaza Constitución and still shows scars from the 1864–65 siege.
- Plaza Constitución · Centro: The leafy main square is the heart of town, ringed by historic buildings and good for an evening stroll.
- Monumento a la Perpetuidad (Cementerio Viejo) · Centro: The old 19th-century cemetery is now an open-air museum of elaborate marble tombs and funerary sculpture.
- Teatro Florencio Sánchez · Centro: An elegant 19th-century theater, one of the oldest in Uruguay, that still hosts plays and concerts.
- Meseta de Artigas · Chapicuy (north of Paysandú): A high bluff above the Río Uruguay where Artigas camped in 1815, with a monument and wide river views.
- Semana de la Cerveza · Balneario Municipal: Paysandú's long-running beer festival during Easter week brings concerts, food stalls and crowds to the riverside.